The History of Vitamins

Most of us think nutrient depletion of processed food is a recent problem, but it’s been going on for more than a century. In fact, efforts to solve that very problem in the early 1900s led to the development of today’s most popular dietary supplement: the multivitamin.

A timeline of the storied history of multivitamins

Most of us think nutrient depletion of processed food is a recent problem, but it’s been going on for more than a century. In fact, efforts to solve that very problem in the early 1900s led to the development of today’s most popular dietary supplement: the multivitamin. But before the supplement could be invented, scientists had to discover the existence of substances we now call vitamins.

When the 20th century began, only three essential nutrients were recognized in food: protein, carbohydrates, and fat. Poor sanitation and hygiene were viewed as the root of all disease, and the solution was sterilizing food to get rid of bacteria, mold, and toxins. Rice was polished, and other grains were milled to eliminate husks. But despite prolonging shelf life, there were some harmful consequences, unknown at the time

The processing of grains destroyed vital B vitamins and led to higher incidence of two of the era’s common diseases: pellagra, a deficiency of niacin, whose symptoms include sores and delusions; and beriberi, a deficiency of vitamin B1, or thiamine, which damages nerves and can lead to paralysis.

Sterilizing milk with heat destroyed vitamin C, and rates of scurvy―(bleeding gums and fatigue are common symptoms)―increased among children in affluent families. These were the people who had access to the “best” food, or so they thought, so these trends were a mystery.

Aha! Vitamin Discovery

Scientists who were trying to solve these problems began to discover that food contained more than three nutrients. One called these other essential compounds “accessory substances.” Another, Casimir Funk, coined the term “vitamine” in a 1912 scientific paper, and the word later became “vitamin.” Funk, who is credited with discovering vitamins, proposed the idea that various diseases could be cured with nutrients and during the next few decades, he and other scientists identified various vitamins we now take for granted. But that process took a while.

Early Vitamin Products

The initial vitamin discovery spawned various products, such as Yeast Vitamine, Double Strength Yeast and Iron Concentrate, and Super Vitamins. They typically contained “vitamin B” (individual B vitamins had not been identified yet) from yeast and various other ingredients.

Mastin’s Yeast Vitamon Tablets was a leading product of the day and likely most similar to today’s multi, with vitamins A, B, and C, iron, calcium, and Nux vomica, a homeopathic remedy for heartburn. Its label claimed: “This preparation contains vitamines together with other ingredients which should prove of value in helping to improve the appetite, aid digestion, correct constipation, clear the skin, increase energy, and, as a tonic, to assist in putting on weight in weakened, run down conditions due to malnutrition.”

The medical profession wasn’t happy about consumers buying supplements. “The claims set forth on the labels of the medicinal values of these preparations are extravagant and misleading,” said an article in a 1922 issue of the Journal of the American Medical Association.

Medical Recognition of Multivitamins

Despite the criticism, in that same year, another medical journal enthusiastically promoted a multivitamin made by a leading pharmaceutical company: Metagen from Parke, Davis & Co., (now part of Pfizer). Sold to doctors to prescribe to patients, Metagen contained vitamins A, B, and C and, according to a glowing review in American Family Physician, could improve health for virtually anyone, including infants and people with major diseases of the era.

The article concluded: “In view of the radical change that has come over the accepted methods of preparing and supplying the food of the nation, it seems that the discovery of the vitamines and the elaboration of Metagen, the most available preparation of vitamines for the use of the physician, are not only timely but of the greatest importance in their bearing upon the health and well-being of the population.”

Around the same time, the American Medical Association endorsed Oscodal, a supplement created by Casimir Funk. The man who discovered vitamins had also invented a process to get vitamins A and D from cod-liver oil into a sugar-coated pill as an alternative to the unpleasant taste of cod-liver oil.

During the rest of the 1920s and into the ’30s, more nutrients were documented and more multivitamin-type products became available. “Vim,” “vigor,” and “pep” were promoted benefits. Vitamin ingredients were being extracted from food, but in the late 1930s, methods were developed to synthesize them in a lab, cutting costs and setting the stage for wider use.

A Nutritional Milestone with Recommended Dietary Allowances

As American men were called for military service during WWII,  one-third were found to suffer from disabilities known to stem from poor nutrition. In response, President Franklin D. Roosevelt convened the National Nutrition Conference for Defense in 1941. The result was the first set of government-sponsored Recommended Dietary Allowances (RDAs) for six vitamins and two minerals (see Essential Vitamins and Minerals on p.64). Although more nutrients have been discovered and added to the list since then, the first RDAs began to define the multivitamin as we know it today. The first One-A-Day appeared in 1943. “That’s where we really started to see the multivitamin as a kitchen-table product,” says Daniel Fabricant, PhD, executive director of the Natural Products Association. By the late 1950s, many multis were sold in apothecary-style bottles and promoted to be kept on the table, next to the salt and pepper shakers.

Legal Battles Over Megavitamin Therapy

Megavitamin therapy benefits began to be documented by Linus Pauling and other scientists in the 1960s, and by the 1970s, there were many high-dose multivitamins. The FDA responded by trying to regulate vitamins as prescription drugs. Lobbying and legal actions in the decades since then, have preserved consumers’ freedom of choice.

Quality Focus

Although many multis, such as those typically designed for sale in drug stores, contain synthetic ingredients and artificial additives, some companies have chosen to offer higher-quality products. For example, MegaFood began making vitamins from real food in 1973, and others began using plant-based ingredients even earlier.

Greater Variety

Over time, more nutrients and superfoods have been discovered and incorporated into multivitamins, and detailed regulations ensure quality control. Today, we have many choices: multivitamins made with ingredients that are raw, food-based, strictly plant-based, non-GMO, gluten-free, soy-free, or free of other food allergens. Many products are designed for different stages of life, from childhood through child-bearing, for older age groups, and for specific concerns such as heart health. Multivitamin “pills” now come in liquids, powders, chewables, and gummies.

Basic Problem persists

Despite more than a century of research and innovation, nutritional shortfalls continue. And although nutritional deficiencies today may not be severe enough to cause beriberi or pellagra, they still impact our health. “The bottom line is that most people are just not getting the nutrients they need,” says Tieraona Low Dog, MD, author of Fortify Your Life, “even if they believe they eat a healthy diet.”


A 1977 ad for a plant-based multi with herbs.

A 1977 ad for a plant-based multi with herbs.


A 1977 ad for a vegetarian multivitamin without additives or animal products, such as fish liver oil, oyster shells, bone meal, or desiccated liver.


A 1984 ad for a broad-spectrum, high-dose multivitamin with enzymes, amino acids, and superfoods such as bee pollen, wheat grass, barley grass, and spirulina.

A 1984 ad for a broad-spectrum, high-dose multivitamin with enzymes, amino acids, and superfoods such as bee pollen, wheat grass, barley grass, and spirulina.


Essential Vitamins and Minerals

The list of vitamins and minerals for which the U.S. government has set requirements has grown over the years.

  • 1941: Vitamins A, B1, B2, B3, C, and D, calcium, and iron.
  • 1968: Vitamins E, B6, and B12, and magnesium join the list, and more are added in later years.
  • Today: Vitamins A, B1 (thiamin), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine,) B7 (biotin), B9 (folic acid), B12 (cobalamin), C, D, E, K, choline, calcium, chromium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, selenium, zinc, potassium, and chloride.

Early Multivitamin Claims

In 1922, multivitamin-type products were advertised for relief from pimples, blackheads, boils, constipation, malnutrition, nervous deficiency, physical breakdown, brain fog, general debility, run-down conditions, to “loosen up the slime and accumulated bile and clean the system,” to improve energy and digestion, and help weak, malnourished people gain weight.

Multivitamins Guard Against Shortfalls

A study of more than 10,000 American adults, published in The Journal of Family Practice, found that people who take multivitamins are much less likely to lack essential vitamins and minerals.

Percent of American adults who are getting basic, adequate amounts of key nutrients

 Vitamin People taking multivitamin and mineral supplements on at least 25 days per month People taking no supplements
Vitamin D 98% 4%
Calcium 89% 62%
Vitamin E 100% 12%
Vitamin K 72% 32%
Magnesium 82% 42%
Vitamin A 100% 47%
Vitamin C 99% 50%
Zinc 100% 85%

 

More than 90 percent of Americans fall short on at least one essential vitamin or mineral.­—The Journal of Family  Practice, September, 2016.


Natural Vitality Organic Life Vitamins features key vitamins, minerals, superfruits, and veggies in an easy-to-take, naturally sweetened liquid.

Natural Vitality Organic Life Vitamins features key vitamins, minerals, superfruits, and veggies in an easy-to-take, naturally sweetened liquid.


Paradise ORAC Energy Earth’s Blend One Daily Multivitamin with Iron or No Iron Added are whole-food-derived vitamin and mineral formulas with added probiotics and herbs to support overall health.

Paradise ORAC Energy Earth’s Blend One Daily Multivitamin with No Iron Added are whole-food-derived vitamin and mineral formulas with added probiotics and herbs to support overall health.Paradise ORAC Energy Earth’s Blend One Daily Multivitamin with Iron are whole-food-derived vitamin and mineral formulas with added probiotics and herbs to support overall health.


Garden of Life mykind Organics Men’s Once Daily& Women’s Once Daily include nutrients specific to the needs of men and women made from organic, non-GMO Project Verified whole  foods.

Garden of Life mykind Organics Men’s Once Daily& Women’s Once Daily include nutrients specific to the needs of men made from organic, non-GMO Project Verified whole foods.Garden of Life mykind Organics Men’s Once Daily& Women’s Once Daily include nutrients specific to the needs of women made from organic, non-GMO Project Verified whole foods.


SmartyPants Adult Complete is a tasty gummy formulated for adults that includes a range of vitamins many of us don’t get enough of in our daily diets.

SmartyPants Adult Complete is a tasty gummy formulated for adults that includes a range of vitamins many of us don’t get enough of in our daily diets.


Natural Factors Whole Earth and Sea Men’s and Women’s Multivitamin & Mineral use whole-food sources of key vitamins, minerals, along with important enzymes and phytonutrients.

Garden of Life mykind Organics Men’s Once Daily& Women’s Once Daily include nutrients specific to the needs of women made from organic, non-GMO Project Verified whole foods.Garden of Life mykind Organics Men’s Once Daily& Women’s Once Daily include nutrients specific to the needs of men made from organic, non-GMO Project Verified whole foods.